Journal
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Volume 257, Issue -, Pages 64-69Publisher
ELSEVIER
DOI: 10.1016/j.ejogrb.2020.12.016
Keywords
HIV; Preeclampsia; sE-selectin
Categories
Funding
- College of Health Sciences, University of KwaZulu-Natal
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This study found that serum sE-selectin levels were significantly elevated in HIV-negative women with preeclampsia compared to those with normal pregnancies. There were statistical differences in gestational age, blood pressure, and baby weight across the study groups.
Objective: To determine the serum concentration of soluble E-selectin (sE-selectin) in HIV associated preeclampsia. Study Design: The study population (n = 72) consisted of normotensive pregnant (n = 36) and preeclamptic (n = 36) women stratified by HIV status (negative vs. positive). Serum concentrations of sE-selectin were quantified using the MilliPlex multiplex immunoassay method. Statistical analyses were conducted using GraphPad Prism software. Results: When stratified by pregnancy type and HIV status, serum sE-selectin levels were elevated in the preeclamptic HIV-negative group compared to the normotensive HIV-negative group (p = 0.0070**). Gestational age, systolic blood pressure, diastolic blood pressure and baby weight were statistically different across the study groups (p < 0.0001). Conclusion: This study demonstrates an elevation of sE-selectin in preeclamptic HIV-negative compared to the normotensive HIV-negative group. However, when stratified by HIV status, there was no significant difference observed in preeclamptic HIV-positive and normotensive HIV-positive groups. The findings of this small-scale study suggest that sE-selectin may be used as a biomarker or an early identifier of preeclampsia. Studies with large numbers should be considered to confirm our findings. (C) 2020 Elsevier B.V. All rights reserved.
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