E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET

Rationale The development of consensus guidelines for interpretation of Prostate-Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) is needed to provide more consistent reports in clinical practice. The standardization of PSMA-PET interpretation may also contribute to increasing the data reproducibility within clinical trials. Finally, guidelines in PSMA-PET interpretation are needed to communicate the exact location of findings to referring physicians, to support clinician therapeutic management decisions. Methods A panel of worldwide experts in PSMA-PET was established. Panelists were selected based on their expertise and publication record in the diagnosis or treatment of PCa, in their involvement in clinical guidelines and according to their expertise in the clinical application of radiolabeled PSMA inhibitors. Panelists were actively involved in all stages of a modified, nonanonymous, Delphi consensus process. Results According to the findings obtained by modified Delphi consensus process, panelist recommendations were implemented in a structured report for PSMA-PET. Conclusions The E-PSMA standardized reporting guidelines, a document supported by the European Association of Nuclear Medicine (EANM), provide consensus statements among a panel of experts in PSMA-PET imaging, to develop a structured report for PSMA-PET in prostate cancer and to harmonize diagnostic interpretation criteria.

Automated summary

The development of consensus guidelines for interpretation of PSMA-PET aims to provide consistent clinical reports, increase data reproducibility in clinical trials, and assist clinicians in making treatment decisions. An expert panel actively participated in a modified Delphi consensus process to implement structured reporting for PSMA-PET. The E-PSMA standardized reporting guidelines supported by the European Association of Nuclear Medicine offer consensus statements among experts in PSMA-PET imaging to harmonize diagnostic interpretation criteria.