Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 28, Issue 5, Pages 1659-1664Publisher
WILEY
DOI: 10.1111/ene.14746
Keywords
clinical outcome; EDSS; MOGAD; optic neuritis
Categories
Funding
- ARSEP foundation
- French State
- Agence Nationale de la Recherche [ANR-551 10-COHO-002]
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The study retrospectively analyzed the long-term outcomes of 61 patients with MOG antibody-associated disease, showing that most patients achieved favorable long-term outcomes, but some experienced severe impairments, particularly visual damage.
Background and objective The prognosis in myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a matter of debate. Our aim was to assess the long-term outcomes of patients with MOGAD. Methods We retrospectively analysed the clinical and paraclinical data of patients from the French nationwide observatory study NOMADMUS who tested positive for MOG antibodies (MOG-IgG) and who had clinical follow-up of at least 8 years from their first episode. Results Sixty-one patients (median [range] age at onset 27 [3-69] years), with a median (mean; range) follow-up of 177 (212.8; 98-657) months, were included. Among 58 patients with a relapsing course, 26.3% relapsed in the first year after onset. Of the 61 patients, 90.2% experienced at least one episode of optic neuritis. At last visit, the median (mean; range) Expanded Disability Status Scale (EDSS) score was 1 (2.12; 0-7.5), 12.5% had an EDSS score >= 6 and 37.5% had an EDSS score >= 3. Of 51 patients with final visual acuity (VA) data available, 15.7% had VA <= 0.1 in at least one eye and 25.5% had VA <= 0.5 in at least one eye. Bilateral blindness (VA <= 0.1) was present in 5.9% of patients. Finally, 12.5% of patients presented bladder dysfunction requiring long-term urinary catheterization. No factor associated significantly with a final EDSS score >= 3 or with final VA <= 0.1 was found. Conclusion Overall long-term favourable outcomes were achieved in a majority of our patients, but severe impairment, in particular visual damage, was not uncommon.
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