Related references
Note: Only part of the references are listed.Activation of Farnesoid X Receptor by Schaftoside Ameliorates Acetaminophen-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammation
Meijing Liu et al.
ANTIOXIDANTS & REDOX SIGNALING (2020)
Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice
Barbara dos Santos et al.
NEUROCHEMICAL RESEARCH (2020)
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury
Valentina Sepe et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators
Simone Schierle et al.
CHEMMEDCHEM (2018)
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
David C. Tully et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri et al.
LANCET (2015)
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)
Daniel Merk et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation
Antimo Gioiello et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Knocking on FXR's Door: The Hammerhead-Structure Series of FXR Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities
Christian Gege et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis
Marina G. Silveira et al.
EXPERT OPINION ON PHARMACOTHERAPY (2014)
Extending the Structure-Activity Relationship of Anthranilic Acid Derivatives As Farnesoid X Receptor Modulators: Development of a Highly Potent Partial Farnesoid X Receptor Agonist
Daniel Merk et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Karen K. Ryan et al.
NATURE (2014)
Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
Giovanni Musso et al.
PROGRESS IN LIPID RESEARCH (2013)
Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms
Danielle A. A. Hollman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)
Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition
Martina Duefer et al.
DIABETES (2012)
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
Hartmut Jaeschke et al.
DRUG METABOLISM REVIEWS (2012)
Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators
Daniel Merk et al.
FUTURE MEDICINAL CHEMISTRY (2012)
Emergency Department Visits for Overdoses of Acetaminophen-Containing Products
Daniel S. Budnitz et al.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2011)
A Formulation-Enabled Preclinical Efficacy Assessment of a Farnesoid X Receptor Agonist, GW4064, in Hamsters and Cynomolgus Monkeys
Po-Chang Chiang et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)
Deanna L. Howarth et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity
Jie Cheng et al.
DRUG METABOLISM AND DISPOSITION (2009)
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
H Jaeschke et al.
TOXICOLOGY LETTERS (2003)
FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits
GR Xu et al.
JOURNAL OF LIPID RESEARCH (2003)
6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
B Goodwin et al.
MOLECULAR CELL (2000)
Identification of a chemical tool for the orphan nuclear receptor FXR
PR Maloney et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
LB Moore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
