DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets

Chemically exfoliated MoS2 (ce-MoS2) nanosheets have been widely used in biomedical and environmental fields. Some in vitro studies demonstrated that ce-MoS2 might induce toxicity. However, the understanding of the mechanism of potential toxicity is lacking. In this study, we found that ce-MoS2 could directly induce breakage of double-stranded DNA with or without an external energy input, making it different from other two-dimensional nanomaterials. In a dark environment, the DNA cleavage exhibited a pH-dependent trend due to reactive oxygen species generation under different pH values. Under photoirradiation, DNA cleavage could be enhanced. This study provides insights into the potential environmental risk and toxicity of ceMoS(2) in the aquatic environment.

Automated summary

Chemically exfoliated MoS2 nanosheets have been widely used in biomedical and environmental fields, but may induce toxicity, especially affecting DNA directly, which sets it apart from other two-dimensional nanomaterials. The study found that the ability of ce-MoS2 to induce DNA cleavage is related to pH value and light irradiation conditions, providing new insights into its potential risks and toxicity in aquatic environments.