4.6 Article

Fluctuating Diffusivity of RNA-Protein Particles: Analogy with Thermodynamics

Journal

ENTROPY
Volume 23, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/e23030333

Keywords

analogy with thermodynamics; fluctuating diffusivity; RNA-protein particles

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By analogizing fluctuating diffusivity to thermodynamics, this study delves into the fluctuating diffusivity of messenger RNA molecules fluorescently fused to a protein in living cells. The research identifies the analogs of internal energy, heat, and work for RNA-protein particles, and shows that a Clausius-like inequality holds for the entropy associated with diffusivity fluctuations. Additionally, the change of the statistical fluctuation distribution is examined from a geometric perspective, contributing to a deeper understanding of fluctuating diffusivity in light of thermodynamic laws.
A formal analogy of fluctuating diffusivity to thermodynamics is discussed for messenger RNA molecules fluorescently fused to a protein in living cells. Regarding the average value of the fluctuating diffusivity of such RNA-protein particles as the analog of the internal energy, the analogs of the quantity of heat and work are identified. The Clausius-like inequality is shown to hold for the entropy associated with diffusivity fluctuations, which plays a role analogous to the thermodynamic entropy, and the analog of the quantity of heat. The change of the statistical fluctuation distribution is also examined from a geometric perspective. The present discussions may contribute to a deeper understanding of the fluctuating diffusivity in view of the laws of thermodynamics.

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