Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 5, Pages 1212-1225Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.02.008
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Funding
- Wayne State University Graduate School, EACPHS, WSU
- Burroughs Wellcome Fund Collaborative Research Travel Grant (BWFCRTG)
- US Department of Defense CDMRP KCRP Idea Development Award [W81XWH1810471]
- US National Institutes of Health, National Cancer Institute (NIH/NCI) [R21CA179652]
- WSU FRAP Grant [142174]
- WSU start up grant [176575]
- U.S. Department of Defense (DOD) [W81XWH1810471] Funding Source: U.S. Department of Defense (DOD)
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Gliomas are highly lethal brain cancers, and delivering drugs into the brain is a major challenge due to the blood-brain barrier. Targeted drug delivery systems using nanoparticles show promising potential for successful glioma treatment. Low-density lipoprotein receptors are a focus for drug delivery research in this area.
Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.
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