Journal
ENDOCRINOLOGY
Volume 158, Issue 2, Pages 199-212Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2016-1801
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Funding
- National Institutes of Health [P01 HD44232, BIRCWH K 12 HD065879]
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Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.
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