Journal
DIABETES
Volume 70, Issue 3, Pages 653-664Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dbi20-0006
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Funding
- National Key R&D Program of China [2019YFA0802502]
- National Natural Science Foundation of China [81925008]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA12030210]
- Key Laboratory of Wuliangye-flavor Liquor Solid-state Fermentation of China National Light Industry [2019JJ005]
- Shanghai Science and Technology Commission [19140903300]
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This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth in the liver, as well as its importance in liver physiology. Deregulated ATF/CREB family signaling is implicated in the progression of various diseases.
The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregulated ATF/CREB family signaling is implicated in the progression of type 2 diabetes, nonalcoholic fatty liver disease, and cancer. This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth and its importance in liver physiology. We also highlight how the disrupted ATF/CREB network contributes to human diseases and discuss the perspectives of therapeutically targeting ATF/CREB members in the clinic.
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