Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production

In this issue of Developmental Cell, Weinreb et al. reveal that loss of the DEAD-box helicase Ddx41 unexpectedly triggers an R-loop-mediated sterile inflammatory cascade which drives HSPC production during embryonic development. Human studies suggest mechanistic conservation for inflammation in DDX41-associated hematologic disease, uncovering a potential route for future therapeutic intervention.

Automated summary

This study uncovers that loss of DEAD-box helicase Ddx41 triggers an inflammatory cascade mediated by R-loop during embryonic development, promoting HSPC production. Human studies suggest conservation of this inflammatory mechanism in DDX41-associated hematologic diseases, providing a potential avenue for future therapeutic interventions.