Journal
DEVELOPMENTAL CELL
Volume 56, Issue 7, Pages 906-918Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2021.02.010
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Funding
- National Institutes of Health under Ruth L. Kirschstein National Research Service Award [T32CA190216-04, F32 CA250129, R01s CA150925, CA190170]
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Autophagy plays a dual role in promoting and inhibiting cancer growth and can affect cancer characteristics by regulating organelle homeostasis. Understanding organelle-specific autophagy may lead to more targeted therapeutic approaches for cancer treatment.
Beginning with the earliest studies of autophagy in cancer, there have been indications that autophagy can both promote and inhibit cancer growth and progression; autophagy regulation of organelle homeostasis is similarly complicated. In this review we discuss pro- and antitumor effects of organelle-targeted autophagy and how this contributes to several hallmarks of cancer, such as evading cell death, genomic instability, and altered metabolism. Typically, the removal of damaged or dysfunctional organelles prevents tumor development but can also aid in proliferation or drug resistance in established tumors. By better understanding how organelle-specific autophagy takes place and can be manipulated, it may be possible to go beyond the brute-force approach of trying to manipulate all autophagy in order to improve therapeutic targeting of this process in cancer.
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