Journal
DEVELOPMENTAL BIOLOGY
Volume 474, Issue -, Pages 62-70Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2021.01.017
Keywords
Synthetic embryology; Self-organization; Boundaries; Bioengineering
Categories
Funding
- Barbara and Gerson Bakar Foundation
- Center for Cellular Construction , an NSF Science and Technology Center [DBI1548297]
- Health Innovation Via Engineering
- Canadian Institute of Health Research
- UC President's Postdoctoral Fellowship Program
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Embryonic tissue boundaries are crucial for cementing newly patterned structures during development and serving as organizing centers for subsequent rounds of morphogenesis. Understanding the complex functions of these boundaries is essential for creating better self-organizing tissues in basic science, drug development, and regenerative medicine.
Embryonic tissue boundaries are critical to not only cement newly patterned structures during development, but also to serve as organizing centers for subsequent rounds of morphogenesis. Although this latter role is especially difficult to study in vivo, synthetic embryology offers a new vantage point and fresh opportunities. In this review, we cover recent progress towards understanding and controlling in vitro boundaries and how they impact synthetic model systems. A key point this survey highlights is that the outcome of self-organization is strongly dependent on the boundary imposed, and new insight into the complex functions of embryonic boundaries will be necessary to create better self-organizing tissues for basic science, drug development, and regenerative medicine.
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