4.5 Article

Anti-inflammatory Effect of Cannabidiol and Palmitoylethanolamide Containing Topical Formulation on Skin in a 12-O-Tetradecanoylphorbol-13-Acetate-Induced Dermatitis Model in Mice

Journal

DERMATITIS
Volume 33, Issue 4, Pages 277-281

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DER.0000000000000722

Keywords

12-O-tetradecanoylphorbol-13-acetate (TPA); atopic dermatitis (AD); cannabidiol (CBD); endogenous cannabinoid system (ECS); palmitoylethanolamide (PEA)

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Funding

  1. Pfizer Independent Grants for Learning and Change - CQ Science

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This study assessed the effects of a topical cannabinoid product on a dermatitis mouse model. The results showed that the formulation significantly reduced ear edema, indicating its anti-inflammatory properties. However, its effects were not as robust as potent topical corticosteroids.
Background Chronic inflammatory skin disorders, such as atopic dermatitis, have significant disease burden worldwide. Although efficacious, the adverse effect profile of topical corticosteroids limits long-term use. As an alternative, cannabinoids have been shown to have anti-inflammatory therapeutic effects. Objective The aim of this study was to assess the effects of a topical cannabinoid product using dermatitis mouse model. Methods Thirty-five mice were randomized into treatment groups. 12-O-tetradecanoylphorbol-13-acetate was used as an irritant on 1 ear with the contralateral ear serving as a control. Ear edema was calipered. The test product containing 0.9% cannabidiol and palmitoylethanolamide was compared with a potent topical corticosteroid. Results Treatment with topical cannabinoid formulation reduced ear edema by 51.27% at 24 hours' and 65.69% at 48 hours' postapplication. Alternatively, mometasone reduced ear edema by 89.82% at 24 hours and 98.25% at 48 hours. Natural reduction (control) in ear edema was 26.32% at 24 hours and 44.21% at 48 hours. Both test groups resulted in significantly decreased edema when compared with baseline (P < 0.05), as well as compared with the negative control group (P < 0.05). Conclusions Significant reduction in ear edema, a marker for localized cutaneous inflammation, could be attributed to anti-inflammatory properties of cannabinoids. Although effects were less robust than topical corticosteroid use, cannabinoid formulations have therapeutic promise for dermatitis.

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