4.5 Review

Asymmetric Organocatalytic Tandem/Domino Reactions to Access Bioactive Products

Journal

CURRENT ORGANIC CHEMISTRY
Volume 25, Issue 13, Pages 1457-1471

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272825666210208142427

Keywords

Total synthesis; bioactive products; enantioselective domino; tandem reactions; organocatalysis; asymmetric catalysis; chirality

Funding

  1. National Centre for Scientific Research: CNRS

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This review discusses the major advancements in the total synthesis of bioactive products using enantioselective organocatalytic domino/tandem reactions as key steps, including those based on asymmetric Michael-initiated domino reactions and aldol-initiated domino/tandem reactions.
Tandem and domino reactions constitute economic methodologies to prepare complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allows direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have already been successfully applied to such syntheses. This review presents major developments in the total synthesis of bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions as key steps. It is divided into three parts, dealing successively with syntheses based on organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated domino/tandem reactions and other domino reactions.

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