Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 66, Issue -, Pages 224-232Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.12.014
Keywords
-
Categories
Funding
- Swiss National Foundation (SNF) [31003A_175445]
- Synapsy grants [51NF40-185897]
- Swiss National Science Foundation (SNF) [31003A_175445] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Semaphorins and Plexins are key molecules involved in setting critical biological steps for central nervous system development, playing roles in axonal development and various other developmental processes. Recent research has shown that Semaphorin/Plexin complexes are crucial regulators of neurogenesis, neural cell migration, and adult gliogenesis.
Semaphorins and Plexins constitute one of the largest family of guidance molecules and receptors involved in setting critical biological steps for central nervous system development. The role of these molecules in axonal development has been extensively characterized but Semaphorins and Plexins are also involved in a variety of other developmental processes, spanning from cell polarization to migration, laminar segregation and neuronal maturation. In this review, we aim to gather discoveries carried in the field of neurodevelopment over the last decade, during which Semaphorin/Plexin complexes have emerged as key regulators of neurogenesis, neural cell migration and adult gliogenesis. As well, we report mechanisms that brought a better understanding of axonal midline crossing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available