Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 66, Issue -, Pages 195-204Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.12.006
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Funding
- European Research Council (ERC Adv Grant GENDEVOCORTEX)
- EOS Programme
- Fondation ROGER DE SPOELBERCH
- Belgian FWO
- Belgian FRS/FNRS
- WELBIO Programmemme
- AXA Research Fund
- Belgian Queen Elizabeth Foundation
- Fondation ULB
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During embryonic development, neural stem/progenitor cells generate different cell types through a dynamic balance between intracellular states and extracellular signalling factors. Some mechanisms in human corticogenesis display unique features, linking temporal features of neurogenesis and human brain evolution.
During embryonic development, neural stem/progenitor cells generate hundreds of different cell types through the combination of intrinsic and extrinsic cues. Recent data obtained in mouse and human cortical neurogenesis provide novel views about this interplay and how it evolves with time, whether during irreversible cell fate transitions that neural stem cells undergo to become neurons, or through gradual temporal changes of competence that lead to increased neuronal diversity from a common stem cell pool. In each case the temporal changes result from a dynamic balance between intracellular states and extracellular signalling factors. The underlying mechanisms are mostly conserved across species, but some display unique features in human corticogenesis, thereby linking temporal features of neurogenesis and human brain evolution.
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