Being superficial: a developmental viewpoint on cortical layer 1 wiring

Functioning of the neocortex relies on a complex architecture of circuits, as illustrated by the causal link between neocortical excitation/inhibition imbalance and the etiology of several neurodevelopmental disorders. An important entry point to cortical circuits is located in the superficial layer 1 (L1), which contains mostly local and long-range inputs and sparse inhibitory interneurons that collectively regulate cerebral functions. While increasing evidence indicates that L1 has important physiological roles, our understanding of how it wires up during development remains limited. Here, we provide an integrated overview of L1 anatomy, function and development, with a focus on transient early born Cajal-Retzius neurons, and highlight open questions key for progressing our understanding of this essential yet understudied layer of the cerebral cortex.

Automated summary

The functioning of the neocortex relies on a complex architecture of circuits, with an important entry point located in the superficial layer 1 (L1) containing inputs and inhibitory interneurons. While evidence suggests L1 plays important physiological roles, understanding of its wiring during development remains limited.