Molecular mechanisms employed by enteric bacterial pathogens to antagonise host innate immunity

Many Gram-negative enteric pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC), Salmonella, Shigella, and Yersinia species have evolved strategies to combat host defence mechanisms. Critical bacterial virulence factors, which often include but are not limited to type III secreted effector proteins, are deployed to cooperatively interfere with key host defence pathways. Recent studies in this area have not only contributed to our knowledge of bacterial pathogenesis, but have also shed light on the host pathways that are critical for controlling bacterial infection. In this review, we summarise recent breakthroughs in our understanding of the mechanisms utilised by enteric bacterial pathogens to rewire critical host innate immune responses, including cell death and inflammatory signaling and cell intrinsic anti-microbial responses such as xenophagy.

Automated summary

Many Gram-negative enteric pathogens have evolved strategies to combat host defence mechanisms by deploying critical bacterial virulence factors to interfere with key host defence pathways. Recent studies have not only contributed to our knowledge of bacterial pathogenesis, but also shed light on the host pathways critical for controlling bacterial infection.