Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 68, Issue -, Pages 173-180Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.10.006
Keywords
Nuclear envelope; Transcription; Lamin Associated Domain; LAP2; GLI; Barrier to autointegration
Categories
Funding
- NIH [R01 2R37-ARO54780]
- Cancer Biology Training Grant
- Stanford MSTP
Ask authors/readers for more resources
The nucleoskeleton and TFs have reciprocal impacts on each other, with LEM proteins playing a key role in dynamic TF trafficking pathways. The nuclear lamina serves not only as a refuge for TF accumulation but also for rapid mobilization and signal stability.
The nucleoskeleton has been associated with partitioning the genome into active and inactive compartments that dictate local transcription factor (TF) activity. However, recent data indicate that the nucleoskeleton and TFs reciprocally influence each other in dynamic TF trafficking pathways through the functions of LEM proteins. While the conserved peripheral recruitment of TFs by LEM proteins has been viewed as a mechanism of repressing transcription, a diversity of release mechanisms from the lamina suggest this compartment serves as a refuge for nuclear TF accumulation for rapid mobilization and signal stability. Detailed mechanisms suggest that TFs toggle between nuclear lamina refuge and nuclear matrix lamin-LEM protein complexes at sites of active transcription. In this review we will highlight emerging LEM functions acting at the interface of chromatin and nucleoskeleton to create TF trafficking networks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available