Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 68, Issue -, Pages 90-97Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.10.005
Keywords
Chromosome organization; Nucleoskeleton; Nuclear actin; Molecular chaperones; Chromatin remodelers
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Funding
- NIH Public Service [R01GM118306, R35GM136660]
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The text discusses the cellular mechanisms dictating chromatin movements, including the roles of epigenetic modifications, transcription factors, and the nucleoskeleton system in chromosome folding and positioning.
Chromosomes are selectively organized within the nuclei of interphase cells reflecting the current fate of each cell and are reorganized in response to various physiological cues to maintain homeostasis. Although substantial progress is being made to establish the various patterns of genome architecture, less is understood on how chromosome folding/positioning is achieved. Here, we discuss recent insights into the cellular mechanisms dictating chromatin movements including the use of epigenetic modifications and allosterically regulated transcription factors, as well as a nucleoskeleton system comprised of actin, myosin, and actin-binding proteins. Together, these nuclear factors help coordinate the positioning of both general and cell-specific genomic architectural features.
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