Mitochondrial dynamics: Shaping and remodeling an organelle network

Mitochondria form networks that continually remodel and adapt to carry out their cellular function. The mitochondrial network is remodeled through changes in mitochondrial morphology, number, and distribution within the cell. Mitochondrial dynamics depend directly on fission, fusion, shape transition, and transport or tethering along the cytoskeleton. Over the past several years, many of the mechanisms underlying these processes have been uncovered. It has become clear that each process is precisely and contextually regulated within the cell. Here, we discuss the mechanisms regulating each aspect of mitochondrial dynamics, which together shape the network as a whole.

Automated summary

Mitochondria form networks that are continually remodeled and adapted to carry out their cellular function. This remodeling is achieved through changes in morphology, number, and distribution, which are dependent on fission, fusion, shape transition, and transport/tethering along the cytoskeleton. Over the past few years, many mechanisms regulating these processes have been uncovered, showing precise and context-dependent regulation within the cell.