4.5 Review

Huntington's Disease: New Frontiers in Therapeutics

Related references

Note: Only part of the references are listed.
Review Immunology

Immunotherapies in Huntington's disease and alpha-Synucleinopathies

Oluwaseun Fatoba et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Clinical Neurology

Medical, Surgical, and Genetic Treatment of Huntington Disease

Christine M. Stahl et al.

NEUROLOGIC CLINICS (2020)

Article Neurosciences

Huntington's Disease Clinical Trials Corner: April 2020

Filipe B. Rodrigues et al.

JOURNAL OF HUNTINGTONS DISEASE (2020)

Article Medicine, General & Internal

Targeting Huntingtin Expression in Patients with Huntington's Disease

Sarah J. Tabrizi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biotechnology & Applied Microbiology

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

Edith L. Pfister et al.

HUMAN GENE THERAPY (2018)

Letter Biotechnology & Applied Microbiology

The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice

Juliette Hordeaux et al.

MOLECULAR THERAPY (2018)

Article Neurosciences

Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases

Magdalena Dabrowska et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Multidisciplinary Sciences

New approaches for brain repair-from rescue to reprogramming

Roger A. Barkers et al.

NATURE (2018)

Review Biotechnology & Applied Microbiology

Therapeutic approaches to Huntington disease: from the bench to the clinic

Nicholas S. Caron et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Medicine, Research & Experimental

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease

Su Yang et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Multidisciplinary Sciences

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Manaswini Sivaramakrishnan et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice

Marta Garcia-Miralles et al.

JCI INSIGHT (2017)

Article Clinical Neurology

Safety/tolerability of the anti-semaphorin 4D antibody VX15/2503 in a randomized phase 1 trial

Christopher LaGanke et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2017)

Article Medicine, General & Internal

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease A Randomized Clinical Trial

Samuel Frank et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Review Cell Biology

Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human Studies

Natalia P. Rocha et al.

MEDIATORS OF INFLAMMATION (2016)

Article Biochemistry & Molecular Biology

Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington's disease

Arlene I. Ramsingh et al.

HUMAN MOLECULAR GENETICS (2015)

Article Cell & Tissue Engineering

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

Wenze Niu et al.

STEM CELL REPORTS (2015)

Article Biotechnology & Applied Microbiology

Intrajugular Vein Delivery of AAV9-RNAi Prevents Neuropathological Changes and Weight Loss in Huntington's Disease Mice

Brett D. Dufour et al.

MOLECULAR THERAPY (2014)

Article Clinical Neurology

A Randomized, Double-Blind, Placebo-Controlled Trial of Pridopidine in Huntington's Disease

Karl Kieburtz et al.

MOVEMENT DISORDERS (2013)

Article Biochemistry & Molecular Biology

Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats

Chia-Rung Liu et al.

Review Clinical Neurology

The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis

Tamara Pringsheim et al.

MOVEMENT DISORDERS (2012)

Article Multidisciplinary Sciences

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

Mireia Garriga-Canut et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biotechnology & Applied Microbiology

Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

Jodi L. McBride et al.

MOLECULAR THERAPY (2011)

Article Multidisciplinary Sciences

Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells

David Mittelman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Immunology

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Maria Bjorkqvist et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Multidisciplinary Sciences

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease

TS Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study

YP Deng et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2004)

Article Biochemistry & Molecular Biology

Inhibition of calpain cleavage of huntingtin reduces toxicity - Accumulation of calpain/caspase fragments in the nucleus

J Gafni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Medicine, General & Internal

Huntingtin aggregation and toxicity in Huntington's disease

G Bates

LANCET (2003)

Article Clinical Neurology

Early and progressive accumulation of reactive microglia in the Huntington disease brain

E Sapp et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2001)