4.8 Editorial Material

Sex Determination and Dosage Compensation: femaleless Is the Link in Anopheles Mosquitoes

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Article Biochemistry & Molecular Biology

femaleless Controls Sex Determination and Dosage Compensation Pathways in Females of Anopheles Mosquitoes

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Summary: The evolutionary puzzle of insect sex determination and dosage compensation pathways has been mostly solved in Drosophila melanogaster, with only terminal genes in the pathway being well conserved. The doublesex (dsx) gene, an ancient sex-determining gene, is present in all studied species except lepidopterans. In Anopheles gambiae, the femaleless (fle) gene controls sex determination in females by regulating splicing of dsx and fruitless (fru) and represents a novel molecular link between sex determination and dosage compensation pathways, making it a potential target for genetic control of malaria vectors.

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