Role of the HIPPO pathway as potential key player in the cross talk between oncology and cardiology

The HIPPO pathway (HP) is a highly conserved kinase cascade that affects organ size by regulating proliferation, cell survival and differentiation. Discovered in Drosophila melanogaster to early 2000, it immediately opened wide frontiers in the field of research. Over the last years the field of knowledge on HP is quickly expanding and it is thought will offer many answers on complex pathologies. Here, we summarized the results of several studies that have investigated HP signaling both in oncology than in cardiology field, with an overview on future perspectives in cardiology research.

Automated summary

The HIPPO pathway is a conserved kinase cascade that affects organ size by regulating proliferation, cell survival, and differentiation. Research in oncology and cardiology fields has been investigating HP signaling and future perspectives in cardiology research. This pathway has the potential to offer important insights for future studies.