Recent advances in transition-metal-mediated Csp2-B and Csp2-P cross-coupling reactions

Arylboron and arylphosphorus compounds represent privileged structural scaffolds in synthetic chemistry for the construction of complex molecules. Transition-metal-mediated C-B and C-P cross-couplings provide a powerful synthetic tool for the construction of arylboron and arylphosphours compunds with reactive functional groups. These reactions are considerably explored for the borylation and phosphorylation of reactive aryl halides using Pd, Ni and Cu-based catalysis. Efforts are made on the utilization of Ru, Rh, Ir, Mn, Co, Fe and Ag based systems to expand the substrate scope to carboxylic acid derivatives and functionalization of C-F and C-H bonds. This comprehensive review covers the developments of the transition-metal-mediated C-sp2-B and C-sp2-P cross-couplings for the period of 2011 to 2020. The reactions are arranged based on the boron and phosphorus coupling partners. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

Arylboron and arylphosphorus compounds are important structures in synthetic chemistry for constructing complex molecules. Transition-metal-mediated C-B and C-P cross-couplings are powerful tools for synthesizing these compounds, allowing for the functionalization of reactive aryl halides. Efforts have been made to expand the scope of these reactions to include carboxylic acid derivatives and the functionalization of C-F and C-H bonds.