Ruthenium-catalyzed C-H bond functionalization in cascade and one-pot transformations

Ruthenium complexes are well known as remarkable pre-catalysts for challenging C-H bond functionalizations. Combining them with other types of chemical reactions in a tandem or one-pot fashion is appealing from a sustainable point of view because it gives access to new strategies to diminish steps devoted to purification and isolation of (sometimes unstable) intermediates. This non-exhaustive review highlights the different approaches enabling these technologies with a particular focus on the understanding for the compatibility of the different reaction sequences. More precisely, ruthenium-catalyzed C-H bond functionalization turned out to be compatible with several organic transformations, metal-mediated reactions and transition metal catalysis. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

Ruthenium complexes are widely recognized as excellent pre-catalysts for challenging C-H bond functionalization reactions, and their combination with other types of chemical reactions can reduce purification and isolation steps, increasing reaction sustainability. Research in this field focuses on the compatibility of different reaction sequences, with a particular emphasis on the compatibility of ruthenium-catalyzed C-H bond functionalization with organic transformations, metal-mediated reactions, and transition metal catalysis.