Polymeric non-spherical coarse microparticles fabricated by double emulsion-solvent evaporation for simvastatin delivery

Polymeric particles with non-spherical shape or coarse surface have distinct advantages for drug delivery, tissue regeneration and immunomodulation respectively, but it is not easy to control polymeric microparticles in required geometry and surface texture simultaneously. In this study, polymeric non-spherical microparticles with coarse surface were successfully prepared by double emulsion-solvent evaporation technique in the presence of ammonium bicarbonate and the formation mechanism was proposed. In addition, simvastatin was encapsulated in poly [lactic-co-(glycolic acid)] (PLGA) non-spherical microparticles with coarse surface by the same technique and the release kinetics in vitro was fitted as well, which not only enrich the encapsulation techniques of liposoluble drugs in polymeric non-spherical carriers but also envision the potential application for alveolar ridge preservation with local delivery of simvastatin.

Automated summary

In this study, polymeric non-spherical microparticles with coarse surface were successfully prepared using double emulsion-solvent evaporation technique, and simvastatin was encapsulated in these particles with fitting release kinetics in vitro, which opens up new possibilities for drug delivery.