Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 199, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111502
Keywords
Polymer; Drug delivery; Nanoparticles; Antibacterial; Wound healing
Funding
- National Natural Science Foundation of China [81703448, 81973261]
- Applied Basic Research Programs of Sichuan Province Science and Technology Department [2019YJ0663]
- Project of Sichuan Provincial Science and Technology Department [2019YJ0661]
- Research Funding for Talents Developing, West China Hospital of Stomatology, Sichuan University [RCDWJS2020-7]
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Polydopamine (PDA) has great potentials in biomedical fields due to its unique physicochemical properties, serving as drug carriers or bioactive agents. This review comprehensively discusses the potentials of PDA-based nano-systems in treating various diseases and addresses concerns in biomedical use.
Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDAbased nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and biosensing. This review aims to provide a comprehensive understanding of PDA, its polymerization mechanisms and the potentials of PDA-based nano-systems in treating various diseases, including cancer, diabetes, inflammation, bacterial infection and Parkinson's disease. In addition, the concerns of PDA in biomedical use are also discussed.
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