Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 199, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111537
Keywords
Cyanine; Fluorescence resonance energy transfer; Photoacoustic imaging; Human serum albumin; Nanoparticle
Funding
- National Key Research and Development Program of China [2017YFC1309100, 2017YFA0205200]
- Fundamental Research Funds for the Central Universities [JB211204, JB211201, JB191208, JB191207, JB191211]
- National Natural Science Foundation of China [32071406, 81671753, 91959124, 81227901, 21804104]
- Subject Booster Program of Xijing Hospital, Fourth Military Medical University [XJZT18MJ65]
- Natural Science Basic Research Plan in Shaanxi Province of China [2019JQ-662, 2019JQ-139]
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The albumin-based FRET nanoprobe Cy5/7@HSA NPs showed high sensitivity and excellent imaging in cell and tumor imaging, indicating its strong potential as a multileveled tumor imaging platform.
Tumor tissue imaging and drug release imaging are both crucial for tumor imaging and image-guided drug delivery. It is urgent to develop a multileveled tumor imaging platform to realize the multiple imaging applications. In this work, we synthesized an albumin-based fluorescence resonance energy transfer (FRET) probe Cy5/7@HSA NPs containing two near-infrared cyanine dyes (CyBI5 and CyBI7) with high FRET efficiency (97 %). Excellent brightness and efficient FRET inside Cy5/7@HSA NPs enabled high-sensitive cell imaging and tumor imaging. This unique nanoprobe imaged 4T1 tumor-bearing mice with high sensitivity (TBR = 5.2) at 24 h post-injection and the dyes penetrated the tumor interior around 4 h post-injection. The release of dyes from nanoprobes was also tracked. This result shows the strong potential of this albumin-based FRET nanoprobe as multileveled tumor imaging platform for in vivo tumor imaging, drug delivery and image-guided surgery.
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