Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 613, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.126062
Keywords
Miniemulsion polymerization; Fluorescence; Magnetic; Functional nanoparticles; Cell imaging
Categories
Funding
- National Natural Science Foundation of China (NNSFC) [51573168, 21908200]
- Natural Science Foundation of Guangdong Province [2019B030301003]
- National Undergraduate Training Programs for Innovation and Entrepreneurship of China [201910338041]
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Magnetic-fluorescent bifunctional nanoparticles were synthesized using a facile miniemulsion polymerization method, resulting in NPs with excellent superparamagnetism and bright fluorescence, as well as low cytotoxicity, making them suitable for cell imaging applications.
Magnetic-fluorescent bifunctional nanoparticles (NPs) have been widely used in biomedical applications. In this work, magnetic-fluorescent bifunctional NPs (P/Fe3O4/Nile Red NPs) were achieved via a facile miniemulsion polymerization. The morphologies and properties of the as-prepared P/Fe3O4/Nile Red NPs were systematically characterized. High-efficiency encapsulation of iron oxide (Fe3O4) and Nile Red in polymer matrix endowed the resultant P/Fe3O4/Nile Red NPs with prominent superparamagnetism and bright fluorescence. Furthermore, the cell viability experiment revealed the low cytotoxicity of P/Fe3O4/Nile Red NPs, indicating the P/Fe3O4/Nile Red NPs are suitable for cell imaging. This work provides a one-pot facile method to fabricate magnetic-fluorescent bifunctional NPs.
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