Journal
CLINICAL NUCLEAR MEDICINE
Volume 46, Issue 7, Pages E353-E354Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000003507
Keywords
F-18-DOPA PET-MRI; anaplastic astrocytoma; aggressive transition
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This case demonstrates the additional value of F-18-DOPA PET in combination with multimodal MRI to differentiate between low and high-grade gliomas.
F-18-DOPA PET-MRI was performed on a 38-year-old man referred for complementary imaging after a brain tumor was discovered, according to EANM/RANO recommendations. We performed a simultaneous PET with 3-T brain MRI, which revealed 2 high F-18-DOPA uptakes, with no multimodal MRI sign of aggressiveness. An awake surgery was performed and found a grade III anaplastic astrocytoma IDH1-R132L mutant, according to the 2016 WHO classification. This was probably the aggressive transition of a grade II diffuse astrocytoma. This case illustrates the added value of F-18-DOPA PET to multimodal MRI to distinguish low- and high-grade gliomas.
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