Multiple Myeloma Presenting as Disseminated Osteoblastic Lesions With Intense 18F-FDG Uptake on PET/CT

A 42-year-old woman presented with numbness and weakness in the lower limbs. The radiograph, MRI, and Tc-99m-MDP bone scintigraphy revealed multiple bone lesions. The lesions were sclerotic on radiograph. Subsequent F-18-FDG PET/CT showed the lesions were disseminated and had intense F-18-FDG uptake. Monoclonal lambda plasmacytoma was confirmed after CT-guided biopsy of the third lumbar vertebral lesion. The laboratory data also showed a monoclonal immunoglobulin G lambda protein in serum and urine immunofixation. The patient was diagnosed as multiple myeloma finally. Multiple myeloma should be in the differential diagnosis scope of multiple osteoblastic lesions with intense F-18-FDG uptake on PET/CT.

Automated summary

A 42-year-old woman presented with numbness and weakness in the lower limbs, and was diagnosed with multiple myeloma after examination, requiring further treatment.