Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a >= 4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15).

Automated summary

This study evaluated the efficacy of oral cefixime 400 mg in the treatment of syphilis, with a successful treatment rate of 87%.