Journal
CLINICAL BIOCHEMISTRY
Volume 92, Issue -, Pages 9-18Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2021.03.003
Keywords
Matrix metalloproteinase-7 cancer; Carcinogen; Therapeutic target; Landmark; Mechanism
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Funding
- National Natural Science Foundation of China [31960175]
- Gansu Youth Science and Technology Fund Program [18JR3RA331]
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MMP-7 is a crucial proteolytic enzyme involved in regulating various human pathophysiological processes, especially in the occurrence and development of cancers. It could serve as a potential tumor biomarker and therapeutic target, providing new diagnostic and prognostic considerations for cancer patients.
Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc and calcium endopeptidases. It can degrade a variety of extracellular matrix substrates and other substrates and plays important regulatory roles in many human pathophysiological processes. Since its discovery, MMP-7 has been recognized as a regulatory protein in wound healing, bone growth, and remodeling. Later, MMP-7 was reported to regulate the occurrence and development of cancers and mediate the proliferation, differentiation, metastasis, and invasion of several types of cancer cells via various mechanisms. Thus, matrix metalloproteinase-7 may be a promising tumor biomarker and therapeutic target. The expression of MMP-7 correlates with the clinical characteristics of cancer patients, and its expression profile is a new diagnostic and prognostic biomarker for a variety of human diseases. Hence, manipulating the expression or function of MMP-7 may be a potential treatment strategy for different diseases including cancers. This review summarizes the role played by MMP-7 in carcinogenesis of several human cancers, underlying mechanisms, and its clinical significance of the occurrence and development of cancers.
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