Journal
CLINICAL AND EXPERIMENTAL MEDICINE
Volume 21, Issue 3, Pages 343-354Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-021-00686-z
Keywords
Albumin; Coronavirus 2; COVID-19; SARS
Categories
Funding
- Universita degli Studi di Sassari
- Sardinian Fondo di Sviluppo e Coesione (FSC)
- Patto per lo Sviluppo della Regione Sardegna [RASSR82005, L.R.7-2017]
- Fondo di Ateneo per la Ricerca 2020
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This study found that lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. Assessment of serum albumin concentrations may assist with early risk stratification and selection of appropriate care pathways.
Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the most threatening pandemic in modern history. The aim of this systematic review and meta-analysis was to investigate the associations between serum albumin concentrations and COVID-19 disease severity and adverse outcomes. A systematic literature search was conducted in PubMed, from inception to October 30, 2020. Sixty-seven studies in 19,760 COVID-19 patients (6141 with severe disease or poor outcome) were selected for analysis. Pooled results showed that serum albumin concentrations were significantly lower in patients with severe disease or poor outcome (standard mean difference, SMD: - 0.99 g/L; 95% CI, - 1.11 to - 0.88, p < 0.001). In multivariate meta-regression analysis, age (t = - 2.13, p = 0.043), publication geographic area (t = 2.16, p = 0.040), white blood cell count (t = - 2.77, p = 0.008) and C-reactive protein (t = - 2.43, p = 0.019) were significant contributors of between-study variance. Therefore, lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. The assessment of serum albumin concentrations might assist with early risk stratification and selection of appropriate care pathways in this group.
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