Journal
CLINICA CHIMICA ACTA
Volume 517, Issue -, Pages 127-132Publisher
ELSEVIER
DOI: 10.1016/j.cca.2021.03.001
Keywords
circRNA; Diabetic cardiomyopathy; ceRNA; Pathogenesis
Categories
Funding
- National Natural Science Foundation of China [81670424, 81900424]
- National Natural Science Foundation of Hunan Province [2018JJ2345, 2019JJ40258, 2019JJ50502]
- Scientific Research Fund of Hunan Provincial Health and Family Planning Commission [B20180058, B20180874]
- project of Research Study and Innovative Experiment Program for College Students in University of South China [2018XJXZ375, 2019131]
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Diabetic cardiomyopathy is a significant chronic cardiovascular complication in diabetic patients, characterized by early diastolic dysfunction, myocardial fibrosis, cardiac hypertrophy, and other pathophysiological events. CircRNAs play critical roles in the pathogenesis of diabetic cardiomyopathy, offering potential for novel prevention and treatment strategies for this condition.
Diabetic cardiomyopathy is an important irreversible chronic cardiovascular complication in diabetic patients. This condition is described as early diastolic dysfunction, myocardial fibrosis, cardiac hypertrophy, systolic dysfunction and other complex pathophysiological events, which ultimately lead to heart failure. Despite these characteristics, the underlying mechanisms resulting in diabetic cardiomyopathy are still unknown. With the developments in molecular biotechnology, increasing evidence shows that circRNAs play critical roles in the pathogenesis of diabetic cardiomyopathy. The purpose of this review is to summarize recent studies on the role of circRNAs in the pathophysiological process to provide novel prevention and treatment strategies for diabetic cardiomyopathy, oxidative stress, inflammation, endothelial dysfunction, myocardial fibrosis and cell death in diabetic cardiomyopathy.
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