Effect of surgical menopause and frontal lobe cognitive function

Objective This study aims to explore the prevalence of decreased frontal lobe function and its associated factors in women with surgical menopause. Methods This study is a retrospective analysis of a cross-sectional study conducted between October 2013 and July 2014. Data from 164 women with surgical menopause were analyzed. The Montreal Cognitive Assessment Thai version (MoCA-T) test was administered by a psychologist. The MoCA frontal lobe function score was derived from visuospatial/executive, abstraction, attention, and verbal fluency tests. Multivariable logistic regression was used to assess data associated with decreased frontal lobe function. Results The mean age of participants was 56.3 +/- 6.9 years, and the mean time since menopause was 11.3 +/- 7.4 years. The prevalence of decreased frontal lobe function score was 73.8%, with an average score of 6.21 +/- 1.84. The independent factor associated with a lower MoCA frontal lobe function score was duration of education greater than 6 years. Conclusion Our study adds information about decreased frontal lobe function in almost three-quarters of women with surgical menopause. Duration of education greater than 6 years was a protective factor. Menopause hormone therapy usage did not seem to increase the detrimental effect on frontal lobe function when initiated in young women with surgical menopause.

Automated summary

This study aimed to explore the prevalence of decreased frontal lobe function in women with surgical menopause, finding that almost three-quarters of participants had decreased frontal lobe function, with education duration greater than 6 years being a protective factor. Menopause hormone therapy did not seem to have a detrimental effect on frontal lobe function when initiated in young women with surgical menopause.