Synergistic effect of T80/B30 vesicles and T80/PN320 mixed micelles with Se/C on nasal mucosal immunity

Selenium doped carbon (Se/C), an easily fabricated material, was found to be bio-active and it can serve as an adjuvant to enhance the immune effect of Tween 80/Brij 30 (T80/630) vesicles and Tween 80/polymer cationic surfactant PN320 (T80/PN320) mixed micelles. The synergistic effect of the combination of T80/B30 vesicles and T80/PN320 mixed micelles with Se/C on nasal mucosal immunity was studied in this work, which might provide theoretical basis for developing the related new adjuvant for nasal immunization of recombinant protein, peptide and split protein vaccine. Since both selenium and carbon were bio-compatible elements, Se/C might be safe for practical applications, and this was also reflected by the low hemolytic activity of the materials. This work not only reports an efficient protocol for adjuvant development, but also significantly expands the application scope of selenium chemistry. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

The study showed that Selenium doped carbon had a synergistic effect on nasal mucosal immunity, potentially serving as a new adjuvant for nasal vaccines. Both selenium and carbon are bio-compatible elements, making Se/C safe for practical applications with low hemolytic activity, expanding the scope of selenium chemistry.