Triclosan affects motor function in zebrafish larva by inhibiting ache and syn2a genes

The widespread use of triclosan in personal care products as an antimicrobial agent is leading to its alarming tissue-bioaccumulation including human brain. However, knowledge of its potential effects on the vertebrate nervous system is still limited. Here, we hypothesized that sublethal triclosan concentrations are potent enough to alter motor neuron structure and function in zebrafish embryos exposed for prolonged duration. In this study, zebrafish embryos were used as vertebrate-animal model. Prolonged exposure (up to 4 days) of 0.6 mg/L (LC50, 96 h) and 0.3 mg/L (

Automated summary

The widespread use of triclosan in personal care products as an antimicrobial agent is causing alarming tissue-bioaccumulation, including in the human brain. This study hypothesized that sublethal triclosan concentrations could alter motor neuron structure and function in zebrafish embryos. The results suggest that prolonged exposure to triclosan could have potential effects on vertebrate nervous systems.