Journal
CHEMOSPHERE
Volume 264, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.128445
Keywords
BPS; Cyst breakdown; Folliculogenesis; JNK signaling; Notch signaling
Categories
Funding
- National Natural Science Foundation of China [31672423]
- Shandong Province Key Research and Development Program [2019GSF107082]
- Taishan Scholar Construction Foundation of Shandong Province [ts20190946]
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BPS has adverse effects on mouse ovarian folliculogenesis, including disrupting germ cell cyst breakdown, reducing oocyte quality, and increasing granulosa cell precursors proliferation. These findings provide new evidence for the adverse effects of BPS on female reproduction.
The female reproductive lifespan is largely determined by the size of primordial follicle pool, which is established in early life. Bisphenol S (BPS), frequently present in plastic products used in daily life, has been demonstrated as an exogenous estrogen-like endocrine disrupting chemical interfering with the endocrine and reproductive systems. However, the molecular mechanisms of its reproductive toxicity remain to be determined. In the present study, we focused on the effect of BPS on the early ovarian folliculogenesis of mice. Our in vivo experiments showed that the treatment with BPS at 2 and 10 mu g/kg body weight/day for 3 days induced abnormal germ cell cyst breakdown and primordial follicle assembly in the mouse ovary, further affecting later ovarian differentiation and reducing oocyte quality. In addition, our in vitro study demonstrated that BPS could interact with estrogen receptors (ERs) to induce phosphorylation of JNKs, which is responsible for reducing oocyte adhesion in cysts. Meanwhile, BPS exposure up-regulated Notch signaling pathway to increase the proliferation of granulosa cells precursors. Our study provided new evidence for the adverse effects of BPS on female reproduction, especially after perinatal exposure, and elucidated how it works. (C) 2020 Elsevier Ltd. All rights reserved.
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