Journal
CHEMISTRY LETTERS
Volume 50, Issue 5, Pages 1062-1065Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.210051
Keywords
Nickel catalysis; Hydroboration; In situ generated 1,3-dienes
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This study describes the reaction conditions and products of nickel-catalyzed 1,2-hydroboration, achieving regioselective hydroboration of in situ generated 1,3-dienes to give secondary allylic boronates in high yields.
Transition metal-catalyzed regioselective hydroboration of 1,3-dienes has received continuous interest in the field of organic synthesis. Herein, we describe the nickel-catalyzed Markovnikov 1,2-hydroboration of in situ generated 1,3-dienes with bis(pinacolato)diboron using a secondary homoallyic carbonate as the 1,3-diene and hydride source. The catalytic hydroboration of in situ generated 1,3-dienes proceeded in the presence of Ni(cod)(2)/P(p-MeOC6H4)(3) as the catalyst to give the corresponding secondary allylic boronates in 42-77% yields with high regioselectivity (12 examples).
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