Journal
CHEMISTRY & BIODIVERSITY
Volume 18, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000964
Keywords
Myrothecium; Panax notoginseng; myrothins A– F; antifungal activity
Funding
- National Natural Science Foundation of China [81760632, 31660532, 81660582]
- Yunnan University
- Yunnan Major Science and Technology Project [2019FY003004, 2019ZF003]
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Through the study of six new compounds produced by Myrothecium sp. BS-31, an endophyte isolated from Panax notoginseng, two of these compounds showed weak antifungal activity against pathogenic fungi causing root-rot disease, providing potential for further research on their use as antifungal agents.
Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe-microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A-F (1-6) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B (2) and E (5) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F (6) showed weak activity against F. oxysporum.
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