Journal
CHEMICAL SENSES
Volume 46, Issue -, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjab011
Keywords
chemotherapy; Hedgehog signaling; Notch signaling; organoids; radiotherapy; Wnt signaling
Funding
- National Institutes of Health/National Institute for Deafness and Other Communication Disorders [R21DC016131, R01DC012383, R01DC018489]
- National Cancer Institute [R21CA236480]
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Since the early 20th century, progress in cancer therapies has significantly improved disease prognosis. However, cancer treatments are often accompanied by side effects that can negatively impact patient well-being, with taste impairment being a common and serious side effect.
Since the early 20th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient well-being and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition, and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.
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