Ruthenium-Catalyzed Cycloadditions to Form Five-, Six-, and Seven-Membered Rings

Ruthenium-catalyzed cycloadditions to form five-, six-, and seven-membered rings are summarized, including applications in natural product total synthesis. Content is organized by ring size and reaction type. Coverage is limited to processes that involve formation of at least one C-C bond. Processes that are stoichiometric in ruthenium or exploit ruthenium as a Lewis acid (without intervention of organometallic intermediates), ring formations that occur through dehydrogenative condensation-reduction, s-bond activation-initiated annulations that do not result in net reduction of bond multiplicity, and photochemically promoted ruthenium-catalyzed cycloadditions are not covered.

Automated summary

This article summarizes ruthenium-catalyzed cycloadditions to form five-, six-, and seven-membered rings, with a focus on applications in natural product total synthesis. The content is organized by ring size and reaction type, emphasizing processes that involve the formation of at least one C-C bond. Processes involving stoichiometric ruthenium, dehydrogenative condensation-reduction, s-bond activation-initiated annulations without net reduction of bond multiplicity, and photochemically promoted ruthenium-catalyzed cycloadditions are not covered.