Journal
CHEMICAL ENGINEERING JOURNAL
Volume 417, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129145
Keywords
Fibrous film; Bovine serum albumin; Silver; Antibacterial; Bacteria-infected wound healing
Categories
Funding
- National Natural Science Foundation of China [51903243]
- Shandong Provincial Natural Science Foundation [ZR2017BEM027]
Ask authors/readers for more resources
The G-BSA-Ag films exhibit good extensibility, transparency, and appropriate swelling ability, maintaining a moist and visible healing environment to promote wound healing. The in vitro and in vivo biocompatibility analysis confirms their non-hemolysis, durable antibacterial properties, non-cytotoxicity, and promotion to cell migration.
Antibacterial wound dressings with high flexibility and biocompatibility are attracting increasing attention, especially for applications on flexible body parts such as joints. Bovine serum albumin (BSA) fibrous films were integrated with glycerol to acquire suitable mechanical properties. After the decoration of silver, the as-synthesized G-BSA-Ag films combined the antibacterial properties of silver, the biocompatibility of BSA and the wettability of glycerol, being a promising candidate for bacteria-infected wound dressing. The G-BSA-Ag films exhibited good extensibility (elongation at break > 210% for G-BSA-Ag-22), transmittance (>60% at 600 nm for G-BSA-Ag-22) and appropriate swelling ability, maintaining a moist and visible healing environment to promote wound healing. The in vitro and in vivo biocompatibility analysis of G-BSA-Ag films confirmed their non-hemolysis, durable antibacterial properties, non-cytotoxicity, and promotion to cell migration. Furthermore, the G-BSA-Ag films were applied on a S. aureus-infected mouse wound model, showing accelerated healing rate with reduced inflammatory factor levels, proving their good therapeutic effects on wound healing, and demonstrating good potential in clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available