4.7 Review

Synthesis of cellulose aerogels as promising carriers for drug delivery: a review

Journal

CELLULOSE
Volume 28, Issue 5, Pages 2697-2714

Publisher

SPRINGER
DOI: 10.1007/s10570-021-03734-9

Keywords

Cellulose; Cellulose aerogels; Synthesis; Drug delivery carriers

Funding

  1. National Natural Science Foundation of China [31971605]
  2. International Joint Research Center for Biomass Chemistry and Materials
  3. Shaanxi International Science and Technology Cooperation Base [2018GHJD-19]
  4. Shandong Key RD Program [2019JZZY010407, 2019JZZY010304]
  5. key scientific research plan (Key Laboratory) of Shaanxi Provincial Education Department [17JS016]
  6. Key Laboratory of Pulp and Paper Science and Technology of Ministry of Education/Shandong Province of China [KF201814]

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Cellulose aerogels, as an important raw material, have excellent biocompatibility and chemical functions, making it an ideal carrier for drug delivery with high porosity, large specific surface area, and ultra-light density. They can be used to improve bioavailability and drug loading, inspiring new research in intelligent drug delivery systems.
Cellulose is an important raw material used for the preparation of aerogel materials in life sciences. Cellulose aerogel's excellent biocompatibility, biodegradability, and nontoxicity combined with its multiple chemical functions make it an ideal carrier for drug delivery. Cellulose aerogels offer high porosity, large specific surface area, and ultra-light density. They can be used as drug carriers to improve bioavailability and drug loading. We reviewed the methods used to prepare cellulose aerogels with nanocellulose, renewable cellulose, and cellulose derivatives as raw materials. In addition, we described cellulose aerogels as a drug delivery carrier to inspire work in new drug delivery systems that intelligently use cellulose aerogels. Finally, we described the application prospects of intelligent and responsive cellulose aerogels in drug delivery systems.

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