Journal
CELL STEM CELL
Volume 28, Issue 3, Pages 378-393Publisher
CELL PRESS
DOI: 10.1016/j.stem.2021.02.013
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Funding
- Leukemia and Lymphoma Society Special Fellow award
- Princess Margaret Cancer Centre
- Ontario Ministry of Health
- National Institutes of Health under Ruth L. Kirschstein National Research Service Award [T32CA190216]
- National Institutes of Health [R01CA200707, R01CA243452, R35CA242376, P30CA046934]
- Leukemia and Lymphoma Society Specialized Center of Research grant
- Nancy Carroll Allen Endowed Chair
- Princess Margaret Cancer Foundation
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The article explores the significance of malignant stem cells in leukemia and how targeting energy metabolism can offer more effective treatment options for leukemia patients. It discusses the metabolic properties of leukemia stem cells and compares them with malignant stem cells from solid tumors.
Malignant stem cells have long been considered a key therapeutic target in leukemia. Therapeutic strategies designed to target the fundamental biology of leukemia stem cells while sparing normal hematopoietic cells may provide better outcomes for leukemia patients. One process in leukemia stem cell biology that has intriguing therapeutic potential is energy metabolism. In this article we discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients. In addition, we highlight the similarities and differences in energy metabolism between leukemia stem cells and malignant stem cells from solid tumors.
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