Journal
CELL METABOLISM
Volume 33, Issue 2, Pages 229-230Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2021.01.009
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Funding
- National Institutes of Health [R01DK085252, P01CA233452]
- National Research Foundation of Korea (NRF) - Korea government (MIST) [2020R1C1C1004185]
- National Research Foundation of Korea [2020R1C1C1004185] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study shows that intracellular ER stress can be transmitted to neighboring hepatocytes through connexin 43, leading to exacerbated ER stress and promoting hepatosteatosis and insulin resistance.
Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring hepatocytes via connexin 43, thus propagating ER stress and promoting hepatosteatosis and insulin resistance.
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