Related references
Note: Only part of the references are listed.Comprehensive Network Analysis of Different Subtypes of Molecular Disorders in Lung Cancer
Haoliang Zhang et al.
ONCOLOGIE (2020)
Replication Licensing Aberrations, Replication Stress, and Genomic Instability
Michalis Petropoulos et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase
Xianjin Wu et al.
SCIENTIFIC REPORTS (2019)
The Emerging Roles of mTORC1 in Macromanaging Autophagy
Akpedje S. Dossou et al.
CANCERS (2019)
mTOR as a central hub of nutrient signalling and cell growth
Joungmok Kim et al.
NATURE CELL BIOLOGY (2019)
State-of-the-art strategies for targeting the DNA damage response in cancer
Patrick G. Pilie et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss i n pancreatic cancer
David Muller et al.
JCI INSIGHT (2019)
mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer
Joe Truong Nguyen et al.
ISCIENCE (2019)
The Role of mTOR in Neuroendocrine Tumors: Future Cornerstone of a Winning Strategy?
Giuseppe Lamberti et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration
Joe Truong Nguyen et al.
SCIENCE ADVANCES (2018)
ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer
Franklin C. Harwood et al.
SCIENCE ADVANCES (2018)
mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level
Hao Zeng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
mTOR signalling and cellular metabolism are mutual determinants in cancer
Dirk Mossmann et al.
NATURE REVIEWS CANCER (2018)
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells
Yanling Wang et al.
JCI INSIGHT (2018)
Initial Steps in Mammalian Autophagosome Biogenesis
Daniel Grasso et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)
Emerging functions of the Fanconi anemia pathway at a glance
Rhea Sumpter et al.
JOURNAL OF CELL SCIENCE (2017)
The essential kinase ATR: ensuring faithful duplication of a challenging genome
Joshua C. Saldivar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
P53 suppresses ribonucleotide reductase via inhibiting mTORC1
Zhengfu He et al.
ONCOTARGET (2017)
Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells
Xinhui Zhou et al.
SCIENTIFIC REPORTS (2017)
Targeting ATR in cancer medicine
Raghav Sundar et al.
CURRENT PROBLEMS IN CANCER (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
FANCD2 limits replication stress and genome instability in cells lacking BRCA2
Johanna Michl et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra et al.
SCIENCE (2016)
Increased global transcription activity as a mechanism of replication stress in cancer
Panagiotis Kotsantis et al.
NATURE COMMUNICATIONS (2016)
FANCD2 limits replication stress and genome instability in cells lacking BRCA2
Johanna Michl et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy
Michael Goldstein et al.
ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)
The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability
Huzefa Dungrawala et al.
MOLECULAR CELL (2015)
Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
Y. Aye et al.
ONCOGENE (2015)
DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
Jogitha Selvarajah et al.
ONCOTARGET (2015)
Deoxyribonucleotides as genetic and metabolic regulators
Christopher K. Mathews
FASEB JOURNAL (2014)
Causes of Genome Instability
Andres Aguilera et al.
ANNUAL REVIEW OF GENETICS, VOL 47 (2013)
Up-regulation of cyclin-E1 via proline-mTOR pathway is responsible for HGF-mediated G1/S progression in the primary culture of rat hepatocytes
Kiyomasa Oka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks
Changxian Shen et al.
CANCER RESEARCH (2013)
FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling
Gerald Lossaint et al.
MOLECULAR CELL (2013)
mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells
F. Guo et al.
LEUKEMIA (2013)
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery
Indrajit Chaudhury et al.
NUCLEIC ACIDS RESEARCH (2013)
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
R. M. Jones et al.
ONCOGENE (2013)
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra et al.
SCIENCE (2013)
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Aaron M. Robitaille et al.
SCIENCE (2013)
Comprehensive identification of mutational cancer driver genes across 12 tumor types
David Tamborero et al.
SCIENTIFIC REPORTS (2013)
Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair
Vincenzo D'Angiolella et al.
CELL (2012)
Connecting mTORC1 signaling to SREBP-1 activation
Inan Bakan et al.
CURRENT OPINION IN LIPIDOLOGY (2012)
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation
Kathleen Klotz-Noack et al.
JOURNAL OF CELL SCIENCE (2012)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Quality control in the initiation of eukaryotic DNA replication
John F. X. Diffley
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu et al.
SCIENCE (2011)
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
Woo Joo et al.
SCIENCE (2011)
Eukaryotic Chromosome DNA Replication: Where, When and How?
Hisao Masai et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Kathryn E. Wellen et al.
MOLECULAR CELL (2010)
mTOR and the control of whole body metabolism
Pazit Polak et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
Puck Knipscheer et al.
SCIENCE (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase
Yang David Lee et al.
MOLECULAR CELL (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1
J. Averous et al.
ONCOGENE (2008)
Hypoxia, DNA repair and genetic instability
Robert G. Bristow et al.
NATURE REVIEWS CANCER (2008)
The DNA damage response: Ten years after
J. Wade Harper et al.
MOLECULAR CELL (2007)
TOR signaling is a determinant of cell survival in response to DNA damage
Changxian Shen et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
Dung-Fang Lee et al.
CELL (2007)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
Laura R. Pearce et al.
BIOCHEMICAL JOURNAL (2007)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Ken Inoki et al.
CELL (2006)
mTOR and cancer: insights into a complex relationship
David M. Sabatini
NATURE REVIEWS CANCER (2006)
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
Xin Wang et al.
MOLECULAR CELL (2006)
The functional role of Cdc6 in S-G2/M in mammalian cells
E Lau et al.
EMBO REPORTS (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly et al.
CANCER RESEARCH (2006)
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1
YD Lee et al.
GENES & DEVELOPMENT (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Growing roles for the mTOR pathway
DD Sarbassov et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
MK Holz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation of mammalian target of rapamycin (mTOR) at ser-2448 is mediated by p70S6 kinase
GG Chiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation
M Oehlmann et al.
JOURNAL OF CELL BIOLOGY (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
DC Fingar et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
A Sancar et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2004)
Loss of Geminin induces rereplication in the presence of functional p53
M Melixetian et al.
JOURNAL OF CELL BIOLOGY (2004)
The TOR pathway: A target for cancer therapy
MA Bjornsti et al.
NATURE REVIEWS CANCER (2004)
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1 cyclin B
A Astrinidis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
Y Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A p53-dependent checkpoint pathway prevents rereplication
C Vaziri et al.
MOLECULAR CELL (2003)
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
L Clay-Farrace et al.
EMBO JOURNAL (2003)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor SmI1
XL Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
TOR, a central controller of cell growth
T Schmelzle et al.
CELL (2000)
Share Paper
