Journal
BONE
Volume 81, Issue -, Pages 739-745Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.03.011
Keywords
Epigenetics; Chromatin; Chromatin-modifiers; Osteogenic lineage cells; Acetylation; Methylation
Categories
Funding
- NIAMS [AR68103, AR049069, AR039588]
- NIDCR [DE20194, DE012528]
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Post-translational modifications of chromatin such as DNA methylation and different types of histone acetylation, methylation and phosphorylation are well-appreciated epigenetic mechanisms that confer information to progeny cells during lineage commitment. These distinct epigenetic modifications have defined roles in bone, development, tissue regeneration, cell commitment and differentiation, as well as disease etiologies. In this review, we discuss the role of these chromatin modifications and the enzymes regulating these marks (methyltransferases, demethylases, acetyltransferases, and deacetylases) in progenitor cells, osteoblasts and bone-related cells. In addition, the clinical relevance of deregulated histone modifications and enzymes as well as current and potential therapeutic interventions targeting chromatin modifiers are addressed. (C) 2015 Elsevier Inc. All rights reserved.
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